Thermo Fisher Scientific Phospho-CD136 (RON) (Tyr1238, Tyr1239) Polyclonal Antibody
Human CD136(RON) 단백질의 Tyr1238/1239 인산화 부위를 인식하는 rabbit polyclonal antibody로, WB 및 IHC(P) 응용에 적합. 항원 친화 크로마토그래피로 정제되었으며, 고순도 액상 형태로 제공. 세포막 위치 단백질 검출에 유용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide containing the epitope -EPYYS- with dual phosphorylation sites Y1238/Y1239 of human CD136 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human stomach tissue
- Cellular location: Membrane
Target Information
MST1R (RON) is a receptor tyrosine kinase involved in cell proliferation and motility. The protein is a membrane-spanning, disulfide-linked heterodimer resulting from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding induces tyrosine phosphorylation of the beta chain. Knockout studies show MST1R/RON (-/-) mice fail to survive past the periimplantation period.
The MST1R/RON gene maps to 3p21, a region frequently deleted or mutated in small cell lung and renal carcinoma, and is implicated in epithelial cancer progression. Expression has been documented in many normal human tissues, with ESTs found in libraries from normal and cancerous colon, prostate, stomach, and uterus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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