Thermo Fisher Scientific Troponin T Polyclonal Antibody
Troponin T 단백질을 인식하는 토끼 폴리클로날 항체입니다. Western blot과 IHC(P)에서 검증되었습니다. 인간, 마우스, 랫트 반응성이 있으며, 항원 친화 정제 방식으로 제조되었습니다. 심근 단백질 연구 및 심근 관련 질환 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to inter-segment of human Troponin T Cardiac isoform protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Cardiac Muscle
- Cellular location: T bands of Myofibrils
Target Information
Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, located on the thin filament of striated muscles. It regulates muscle contraction in response to intracellular calcium ion concentration changes. Cardiac Troponin T is essential for proper muscle function and myofibril formation.
In the human heart, four cTnT isoforms are expressed in a developmentally regulated manner. Expression levels are affected by heart failure. Mutations in the Cardiac Troponin T protein are associated with familial hypertrophic cardiomyopathy and dilated cardiomyopathy. The gene undergoes alternative splicing, resulting in multiple tissue-specific isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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