Thermo Fisher Scientific CD68 Monoclonal Antibody (KP1), Alexa Fluor Plus 488
인간 CD68 단백질을 인식하는 KP1 클론 단일클론 항체로 Alexa Fluor Plus 488 형광으로 표지됨. 면역조직화학(IHC) 등 다양한 응용에 사용 가능. 8 µg/mL 농도에서 검증됨. 4℃ 암소 보관, 동결 금지. 연구용으로만 사용.
- 카탈로그번호
- 752068882
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD68 Monoclonal Antibody (KP1), Alexa Fluor Plus 488
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 8 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | KP1 |
| Conjugate | Alexa Fluor™ Plus 488 |
| Excitation / Emission Max | 493 / 518 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.5% BSA, 10% proprietary stabilizer |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Wet ice |
Additional Formats
- Unconjugated (MA5-13324)
- Alexa Fluor 420 (758-0688-82)
- Alexa Fluor 514 (753-0688-82)
- Alexa Fluor 700 (56-0688-82)
- Alexa Fluor Plus 555 (754-0688-82)
- Alexa Fluor Plus 647 (756-0688-82)
- Alexa Fluor Plus 750 (757-0688-82)
- Custom conjugation available upon request
Product Specific Information
The KP1 antibody reacts with human CD68, a member of the sialomucin family related to lysosomal-associated membrane proteins (LAMPs) and scavenger receptors. CD68 is primarily an intracellular protein localized in late endosomes, with smaller amounts on the surface of myeloid-derived cells such as monocytes, macrophages, dendritic cells, neutrophils, basophils, mast cells, myeloid progenitors, and a subset of CD34+ bone marrow progenitor cells.
Although its exact function is not fully elucidated, CD68 is believed to play roles in antigen processing/presentation and in lysosomal membrane protection. Expression has also been reported in activated T cells, subsets of B lymphocytes, and fibroblasts (possibly due to conserved epitopes).
Applications Reported: Flow cytometry, immunoprecipitation, western blotting, and immunohistochemistry (frozen and paraffin-embedded tissues).
Applications Tested: Validated for IHC (paraffin) using high pH antigen retrieval at 8 µg/mL. Optimal dilution should be determined experimentally.
Note: Before use, briefly centrifuge the conjugate solution and use only the supernatant to minimize background due to aggregates.
Target Information
CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein primarily expressed in lysosomes of monocytes and macrophages, and to a lesser extent in dendritic cells and granulocytes. It may be involved in phagocytosis and lysosomal metabolism as well as cell-cell and cell-pathogen interactions.
CD68 expression is observed in interdigitating reticulum cells, histiocytic lymphomas, acute myeloid leukemia (AML), and granulocytic sarcomas. Elevated CD68 levels have been found in CD34+ cells in several malignancies, including AML.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.