Thermo Fisher Scientific STAT5 alpha/beta Monoclonal Antibody (ST5-8F7)
STAT5 alpha/beta 단백질 검출용 Thermo Fisher Scientific의 단클론 항체(ST5-8F7). Western blot, ICC/IF, Flow cytometry, ELISA 등 다양한 응용 가능. 인간, 생쥐, 랫트 반응성. 고순도 Affinity chromatography 정제, PBS buffer 및 sodium azide 포함. 연구용 전용 제품.
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Thermo Fisher Scientific STAT5 alpha/beta Monoclonal Antibody (ST5-8F7)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | View 5 publications |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | - |
| Flow Cytometry (Flow) | - | View 1 publication |
| ELISA | Assay-dependent | - |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ST5-8F7 |
| Immunogen | A peptide corresponding to a conserved amino acid sequence found near the carboxy-terminus of murine STAT5. This peptide encompasses the conserved C-terminal tyrosine phosphorylation site (Y-694) of murine STAT5. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533129 |
Target Information
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators.
This protein mediates responses to various ligands such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and growth hormones.
Activation in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and essential for tumorigenesis.
The mouse counterpart induces expression of BCL2L1/BCL-X(L), suggesting anti-apoptotic function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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