Thermo Fisher Scientific RARA Monoclonal Antibody (OTI2D2), TrueMAB
RARA 단백질을 인식하는 마우스 단클론 항체로, Western blot에 최적화되어 있습니다. 재조합 인간 단백질(aa 52-299)을 면역원으로 사용하였으며, 동결건조 형태로 제공됩니다. Affinity chromatography로 정제되었고, 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 52–299 of human RARA produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20 °C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
RARA (Retinoic Acid Receptor Alpha) is a nuclear receptor for retinoic acid. It forms heterodimers with RXR to bind retinoic acid response elements (RAREs) and regulates gene expression in various biological processes.
In the absence of ligand, RXR-RAR heterodimers recruit corepressors leading to chromatin condensation and transcriptional repression. Upon ligand binding, corepressors dissociate and coactivators are recruited, resulting in transcriptional activation.
RARA is essential for retinoic acid-induced germ cell development, spermatogenesis, skeletal growth, and granulopoiesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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