Thermo Fisher Scientific Dynactin 1 Monoclonal Antibody (6B11)
Dynactin 1 단백질을 특이적으로 인식하는 Mouse 모노클로날 항체로, Western blot 및 Immunoprecipitation에 적합. Human 시료 반응성 검증 완료. 항원 친화 크로마토그래피로 고순도 정제. 연구용으로만 사용 가능.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Dynactin 1 Monoclonal Antibody (6B11)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:1,750 | View 1 publication |
| Immunoprecipitation (IP) | 1:50–1:200 | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6B11 |
| Immunogen | Synthetic peptide corresponding to the N-terminal of human Dynactin 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2539681 |
Product Specific Information
- Detects endogenous levels of DCTN1 (Dynactin 1) at ~150 kDa.
- No cross-reactivity with related proteins.
- Purity >95% confirmed by SDS-PAGE.
Target Information
The Dynactin 1 gene encodes the largest subunit of the dynactin complex, which consists of 10 subunits ranging from 22 to 150 kDa. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in various cellular processes such as:
- ER-to-Golgi transport
- Centripetal movement of lysosomes and endosomes
- Spindle formation and chromosome movement
- Nuclear positioning and axonogenesis
This subunit interacts directly with the dynein intermediate chain and binds microtubules via a conserved CAP-Gly domain in its N-terminus.
Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Mutations in this gene are associated with distal hereditary motor neuronopathy type VIIB (HMN7B), also known as distal spinal and bulbar muscular atrophy (dSBMA).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.