Thermo Fisher Scientific RNASEH2A Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. Their major role is to remove the RNA strand from RNA/DNA hybrids formed during DNA replication and repair.
RNAse H2 is composed of three subunits, all required for RNAse activity. Mutations in RNAse H2A or other subunits are linked to Aicardi-Goutieres syndrome (AGS), a neurological disorder with symptoms similar to viral brain infections, including elevated IFN-alpha levels in cerebrospinal fluid.
Similar conditions occur with mutations in TREX1, suggesting that RNAse H2 and TREX1 may share roles in preventing accumulation of intracellular nucleic acids that trigger inflammatory responses through innate immune system activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.