Thermo Fisher Scientific RNASEH2A Polyclonal Antibody
Rabbit polyclonal antibody targeting human RNASEH2A for WB and IP applications. Recognizes region 249–299 of RNASEH2A. Supplied as liquid, unconjugated form at 1 mg/mL. Ideal for studying RNA/DNA hybrid metabolism and Aicardi-Goutieres syndrome mechani...
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Thermo Fisher Scientific RNASEH2A Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Item | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 249 to 299 of Human Ribonuclease H2, Subunit A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. Their major role is to remove the RNA strand from hybrids formed during DNA replication and repair. RNAse H2 is composed of three subunits, all required for enzymatic activity. Mutations in RNAse H2A or its associated subunits have been linked to Aicardi-Goutieres syndrome (AGS), a neurological disorder with symptoms similar to viral brain infections and elevated IFN-alpha levels in cerebrospinal fluid. Similar pathological features are observed with TREX1 mutations, suggesting that RNAse H2 and TREX1 share roles in preventing accumulation of intracellular nucleic acids and activation of the innate immune system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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