Thermo Fisher Scientific RNASEH2A Polyclonal Antibody
Human RNASEH2A 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot 및 Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific RNASEH2A Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 249–299 of Human Ribonuclease H2, Subunit A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. These enzymes play a major role in removing RNA strands during DNA replication and repair.
RNAse H2 consists of three subunits, all required for enzymatic activity. Mutations in RNAse H2A or other subunits can cause Aicardi-Goutieres syndrome (AGS), a neurological disorder resembling viral brain infections, characterized by elevated IFN-alpha levels in cerebrospinal fluid.
Similar pathological conditions occur with TREX1 mutations, suggesting that RNAse H2 and TREX1 share roles in preventing accumulation of intracellular nucleic acids and regulating innate immune activation.
Usage Note
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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