ELK Biotechnology p53 (phospho Ser6) rabbit pAb
인간 p53 단백질의 Ser6 인산화 부위를 인식하는 rabbit polyclonal antibody로, WB, IHC, IF, IP, ELISA에 사용 가능. 높은 특이성과 재현성을 제공하며, 세포 내 p53 위치 및 기능 연구에 적합. -20°C에서 1년 보관 가능.
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제품명
p53 (phospho Ser6) rabbit pAb
공급업체
ELK Biotechnology
제품 개요
이 항체는 인간 p53 단백질의 Ser6 인산화 부위를 인식하도록 제작된 rabbit polyclonal antibody입니다. 다양한 응용 분야에서 p53의 발현 및 인산화 상태를 분석하는 데 사용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53 |
| Applications | WB; IHC; IF; IP; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunoprecipitation: 2–5 µg/mg lysate ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human p53 around the phosphorylation site of Ser6 (AA range: 1–50) |
| Host Species | Rabbit |
| Storage Conditions | −20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 47 kD |
| Gene ID (Human) | 7157 |
| Human Swiss-Prot No. | P04637 |
| Species Reactivity | Human; Monkey |
세포 내 위치
Cytoplasm, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix, Cytoskeleton (microtubule organizing center, centrosome).
Recruited into PML bodies together with CHEK2 (PubMed:12810724).
Translocates to mitochondria upon oxidative stress (PubMed:22726440) and in response to mitomycin C treatment (PubMed:27323408).
Isoform-specific localization:
- Isoform 1: Predominantly nuclear, cytoplasmic when co-expressed with isoform 4
- Isoform 2: Mainly nuclear, minor cytoplasmic staining
- Isoform 3: Nuclear in most cells, cytoplasmic in some
- Isoform 4: Predominantly nuclear, translocates to cytoplasm
Background
Tumor protein p53 (TP53) in Homo sapiens encodes a tumor suppressor protein with transcriptional activation, DNA binding, and oligomerization domains. The protein responds to cellular stress to regulate target gene expression, inducing cell cycle arrest, apoptosis, senescence, DNA repair, or metabolic changes.
Mutations are associated with various human cancers, including hereditary Li-Fraumeni syndrome.
Alternative splicing and promoter usage produce multiple transcript variants and isoforms, some arising from alternate translation initiation codons (PMIDs: 12032546, 20937277).
[Provided by RefSeq, Feb 2013]
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