ELK Biotechnology p53 (phospho Ser33) rabbit pAb

ELK Biotechnology p53 (phospho Ser33) rabbit pAb

제품 개요

p53 (phospho Ser33) rabbit polyclonal antibody는 인간 p53 단백질의 Ser33 인산화 부위를 인식하도록 제작된 항체로, 종양 억제 단백질 연구에 유용합니다.

제품 정보

세포 내 위치 (Cellular Localization)

• Cytoplasm, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix
• Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
• Recruited into PML bodies together with CHEK2 (PubMed:12810724)
• Translocates to mitochondria upon oxidative stress (PubMed:22726440)
• Translocates to mitochondria in response to mitomycin C treatment (PubMed:27323408)
• Isoform-specific localization:
  • Isoform 1: Predominantly nuclear, also cytoplasmic when expressed with isoform 4
  • Isoform 2: Mainly nuclear, minor cytoplasmic staining
  • Isoform 3: Nuclear in most cells, cytoplasmic in some
  • Isoform 4: Predominantly nuclear, translocates to cytoplasm

Background

Tumor protein p53 (TP53) is a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. It responds to diverse cellular stresses to regulate expression of target genes, inducing cell cycle arrest, apoptosis, senescence, DNA repair, or metabolic changes. Mutations in TP53 are associated with various human cancers, including hereditary cancers such as Li-Fraumeni syndrome.
Alternative splicing and alternate promoter usage result in multiple transcript variants and isoforms. Additional isoforms may arise from alternate translation initiation codons (PMIDs: 12032546, 20937277).
[Provided by RefSeq, Feb 2013]