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ELK Biotechnology Neu (phospho Tyr1221/Y1222) rabbit pAb
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HER2 인산화 부위(Tyr1221/Y1222)를 인식하는 토끼 폴리클로날 항체. WB, IHC, IF, IP, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 세포막 및 핵 위치 단백질 검출에 적합. -20°C에서 1년 보관.
- 판매단위
- pk
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ELK Biotechnology ES1363-100UL Neu (phospho Tyr1221/Y1222) rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES1363-50UL Neu (phospho Tyr1221/Y1222) rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Neu (phospho Tyr1221/Y1222) rabbit pAb
제품명
Neu (phospho Tyr1221/Y1222) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ERBB2; HER2; MLN19; NEU; NGL; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340 |
| Applications | WB; IHC; IF; IP; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunoprecipitation: 2–5 µg/mg lysate ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human HER2 around the phosphorylation site of Tyr1221/Tyr1222 (AA range: 1191–1240) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 180 kDa |
| Gene ID (Human) | 2064 |
| Human Swiss-Prot No. | P04626 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Isoform 1: Cell membrane; Single-pass type I membrane protein; Early endosome; Cytoplasm (perinuclear region); Nucleus. Translocation to the nucleus requires endocytosis and importin beta-1/KPNB1 mediation. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles. Isoform 2: Cytoplasm, Nucleus. Isoform 3: Cytoplasm, Nucleus. |
| Background | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. The protein lacks its own ligand-binding domain but forms heterodimers with ligand-bound EGF receptor family members, stabilizing ligand binding and enhancing downstream signaling via MAPK and PI3K pathways. Allelic variations at amino acid positions 654 and 655 (isoform a) have been reported. Amplification or overexpression is associated with cancers such as breast and ovarian tumors. Alternative splicing results in several transcript variants. |
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