Thermo Fisher Scientific PSD-95 Monoclonal Antibody (7E3), APC
PSD-95 단백질 검출용 Thermo Fisher Scientific의 단일클론 항체로, APC 형광 표지 적용. WB, IHC, ICC 등 다양한 응용 가능. 높은 특이성과 재현성 제공. 연구용으로만 사용.
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Thermo Fisher Scientific PSD-95 Monoclonal Antibody (7E3), APC
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7E3 |
| Immunogen | Recombinant rat PSD-95 |
| Conjugate | APC |
| Excitation/Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.2, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931594 |
Available Formats
- FITC (Catalog: MA5-45141)
- PerCP (Catalog: MA5-45142)
- Custom conjugation available upon request
Product Specific Information
1 µg/mL was sufficient for detection of PSD-95 on 20 µg rat brain tissue extract by ECL immunoblot analysis using Goat Anti-Mouse IgG: HRP as the secondary.
Detects approximately 100 kDa. An additional protein of >100 kDa is also detected. Additional cross-reactive bands are detected at approximately 75 kDa and 50 kDa in rat and mouse samples.
Target Information
Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is a membrane-associated protein found in postsynaptic density of forebrain neurons and certain presynaptic structures in the cerebellum.
PSD-95 contains three PDZ domains, one SH3 domain, and one Guanylate Kinase (GuK) domain. It participates in clustering of NMDA receptors and Shaker-type potassium channels at the synaptic membrane in CNS neurons.
PSD-95 interacts with proteins sharing a C-terminal T/SXV motif, including NMDA receptors, β1 adrenergic receptor, serotonin receptors, sodium and potassium channel subunits.
Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but has its own PDZ domain, can associate with PSD-95 through PDZ-PDZ interaction.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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