Thermo Fisher Scientific PSD-95 Monoclonal Antibody (7E3), APC

Thermo Fisher Scientific PSD-95 Monoclonal Antibody (7E3), APC

Applications and Tested Dilutions

Product Specifications

Available Formats

• FITC (Catalog: MA5-45141)
• PerCP (Catalog: MA5-45142)
• Custom conjugation available upon request

Product Specific Information

1 µg/mL was sufficient for detection of PSD-95 on 20 µg rat brain tissue extract by ECL immunoblot analysis using Goat Anti-Mouse IgG: HRP as the secondary.
Detects approximately 100 kDa. An additional protein of >100 kDa is also detected. Additional cross-reactive bands are detected at approximately 75 kDa and 50 kDa in rat and mouse samples.

Target Information

Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is a membrane-associated protein found in postsynaptic density of forebrain neurons and certain presynaptic structures in the cerebellum.
PSD-95 contains three PDZ domains, one SH3 domain, and one Guanylate Kinase (GuK) domain. It participates in clustering of NMDA receptors and Shaker-type potassium channels at the synaptic membrane in CNS neurons.
PSD-95 interacts with proteins sharing a C-terminal T/SXV motif, including NMDA receptors, β1 adrenergic receptor, serotonin receptors, sodium and potassium channel subunits.
Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but has its own PDZ domain, can associate with PSD-95 through PDZ-PDZ interaction.

Usage Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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