Thermo Fisher Scientific Beta-Synuclein Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:200

Product Specifications

Product Specific Information

Reconstitution:
25 µL, 50 µL, or 0.2 mL double distilled water (DDW), depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, store small aliquots at -20°C.
Avoid multiple freezing and thawing cycles.
Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

The synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates, they are encoded by three different genes. Synucleins have been implicated in major diseases such as Alzheimer’s (AD), Parkinson’s disease (PD), and breast cancer.

• In AD, a peptide derived from alpha-synuclein forms a component of plaque amyloid.
• In PD, alpha-synuclein accumulates in Lewy bodies.
• An allele of alpha-synuclein is linked to familial PD cases.
• In breast cancer, increased gamma-synuclein expression correlates with disease progression.

Synucleins appear to play a role in membrane plasticity in developing song control systems of songbirds.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.