Thermo Fisher Scientific CDK8 Monoclonal Antibody (6E5)
CDK8 단백질을 인식하는 Thermo Fisher Scientific의 단일클론 항체. Western blot 및 ELISA에 적합하며 인간, 생쥐, 랫트 반응성. 액상 형태로 제공되며 PBS 버퍼에 보존제 없이 -20°C에서 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.03 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6E5 |
| Immunogen | CDK8 (NP_001251, 375–464 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
QQQGNNHTNG TGHPGNQDSS HTQGPPLKKV RVVPPTTTSG GLIMTSDYQR SNPHAAYPNP GPSTSQPQSS MGYSATSQQP PQYSHQTHRY
Target Information
CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with Cyclin C. CDK8 belongs to the cyclin-dependent kinase (CDK) family, which regulates cell cycle progression. Members such as p34/Cdc2 and Cdk2 function late in the cycle, while Cdk4 and Cdk6 are involved in G1 to S transition. The human CDK8-Cyclin C complex may interact with RNA polymerase, influencing transcription mechanisms related to cell division.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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