Thermo Fisher Scientific CDKN1A Monoclonal Antibody (OTI7C8), TrueMAB
CDKN1A(p21) 단백질을 인식하는 Mouse IgG2b 단클론 항체로, Western blot 및 IHC(P) 적용 가능. 인간 시료 반응성, 비결합형 형태로 1 mg/mL 농도. 종양 억제 단백질 연구 및 세포주기 조절 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7C8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 2–164 of human CDKN1A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Protein p21 (CDKN1A) is a tumor suppressor protein that inhibits Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53.
It plays a key role in the cellular response to genotoxic stress and regulates cell cycle progression by blocking the G1/S and G2/M transitions after DNA damage.
In the cytoplasm, p21 exhibits anti-apoptotic properties by inhibiting caspase 3 and apoptotic kinases ASK1 and JNK.
P21 demonstrates dual roles in carcinogenesis, functioning as both a tumor suppressor and an oncogene depending on cellular context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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