Thermo Fisher Scientific PSMA1 Polyclonal Antibody
Thermo Fisher Scientific의 PSMA1 Polyclonal Antibody는 proteasome 20S C2 서브유닛을 검출하는 고품질 항체로, Western blot 및 면역침강에 적합합니다. Rabbit IgG 기반의 비결합형 액상 항체이며, 다양한 종(인간, 마우스, 랫 등)에 반응합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific PSMA1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | View 2 publications |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
| RNA Immunoprecipitation (RIP) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Hamster, Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic Peptide: C P(249) A D E P A E K A D E P M E H(263) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2171381 |
Product Specific Information
PA1-963 detects the proteasome 20S C2 subunit from canine, hamster, human, mouse, and rat tissues and cells.
It has been successfully used in Western blot procedures, detecting a 29 kDa protein representing the proteasome 20S C2 subunit from rat brain extract.
The immunizing peptide corresponds to amino acid residues 249–263 from the C-terminus of human proteasome 20S C2 subunit.
This sequence is 93% conserved in rat and chicken proteins and 87% conserved in mouse protein.
The immunizing peptide (Cat. # PEP-100) is available for neutralization and control experiments.
Target Information
Proteolytic degradation is essential for maintaining appropriate levels of short-lived and regulatory proteins involved in metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway degrades most cytosolic and nuclear proteins, while others are processed through the vacuolar pathway involving endosomes, lysosomes, and the endoplasmic reticulum.
The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped complex (~2.5 MDa) consisting of a 20S core and one or two 19S regulatory subunits.
The 19S subunits recognize ubiquitinated proteins and facilitate their unfolding and translocation into the 20S core.
Defects in this pathway are associated with diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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