Thermo Fisher Scientific KCNMB1 Polyclonal Antibody
KCNMB1 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 IHC에 사용 가능. 인간, 마우스, 랫트 반응성. 동결건조 형태로 제공되며, 재구성 후 사용. 칼슘 활성 칼륨 채널 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal region of KCNMB1 (Maxi K channel subunit beta-1) conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage buffer | Whole serum |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity: KCNMB1.
Target Information
Potassium channels are ubiquitously expressed proteins with diverse functions in excitable and non-excitable cells.
The large conductance, calcium-activated potassium channel (Maxi K⁺) is unique in being activated by both intracellular calcium increase and membrane depolarization.
The channel core forms a Maxi K⁺ alpha homotetramer with voltage sensor and calcium binding domains.
In vascular smooth muscle, an auxiliary beta-subunit (KCNMB1) associates in a 1:1 ratio, reducing the calcium concentration required to open the pore by 5–10 fold.
Maxi K⁺ beta-subunit plays a key role in regulating blood flow and blood pressure and is a potential therapeutic target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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