Thermo Fisher Scientific DKK1 Recombinant Rabbit Monoclonal Antibody (SC06-86)
Recombinant rabbit monoclonal antibody targeting Human DKK1. Validated for WB, IHC, ICC, and Flow applications with high specificity and sensitivity. Expressed in HEK293 cells, purified by Protein A, and supplied as a liquid form for consistent researc...
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | View 2 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:1000 | |
| Immunocytochemistry (ICC/IF) | 1:50–1:500 | |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SC06-86 |
| Immunogen | Synthetic peptide within Human DKK1 aa 225–266 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809515 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
DKK-1 is a member of the DKK protein family (DKK-1, DKK-2, DKK-3, DKK-4). Initially identified as a Xenopus head-forming molecule, DKK-1 acts as an antagonist for Wnt signaling. It regulates the Wnt/β-catenin pathway by forming inhibitory complexes with LRP5 and LRP6, essential co-receptors for Wnt ligands.
By inhibiting Wnt/β-catenin signaling, DKK-1 supports anterior development. Mice deficient in DKK-1 lack head formation and die during embryogenesis.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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