Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (5H10)
CD8α 단일클론 항체(5H10)는 T 세포 표지자인 CD8을 특이적으로 인식하며, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 사용됩니다. Rat IgG2b 형식의 비결합 항체로, 4°C에서 보관하며 연구용으로 적합합니다.
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Applications and Publications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 24 publications |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | - | View 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 2 publications |
| Immunocytochemistry (ICC/IF) | - | View 5 publications |
| Flow Cytometry (Flow) | Assay-dependent | View 58 publications |
| Miscellaneous PubMed (Misc) | - | View 29 publications |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Fruit fly, Insect, Mouse |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5H10 |
| Immunogen | Con A-stimulated BALB/c splenic T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10392843 |
Available Conjugate Formats
- Alexa Fluor 488
- Alexa Fluor 647
- Alexa Fluor 700
- APC
- APC-Alexa Fluor 750
- FITC
- Pacific Blue
- Pacific Orange
- PE
- PE-Cyanine7
- PE-Texas Red
- PerCP
- Request custom conjugation
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein belonging to the immunoglobulin receptor family. It plays a key role in signal transduction, T cell differentiation, and activation.
CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules. CD8α is essential for MHC-I binding and is also found as a homodimer on subsets of T cells, NK cells, monocytes, and dendritic cells.
Binding of MHC-I/peptide complexes on antigen-presenting cells recruits Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are crucial for pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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