Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (5H10), APC
CD8α 단백질을 인식하는 Rat IgG2b 모노클로날 항체로, APC 형광체가 결합되어 있습니다. Flow Cytometry에 적합하며 Mouse 시료에 반응합니다. 고순도 Affinity chromatography로 정제되었으며, 4°C에서 안정적으로 보관 가능합니다.
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Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (5H10), APC
Applications
- Flow Cytometry (Flow): Assay-dependent
View 9 publications - Miscellaneous PubMed (Misc): -
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5H10 |
| Immunogen | Con A-stimulated BALB/c splenic T cells |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10375296 |
Additional Formats
- Alexa Fluor 488
- Alexa Fluor 647
- Alexa Fluor 700
- APC-Alexa Fluor 750
- FITC
- Pacific Blue
- Pacific Orange
- PE
- PE-Cyanine7
- PE-Texas Red
- PerCP
- Request custom conjugation
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family, crucial in T cell signal transduction, differentiation, and activation.
CD8 is mainly expressed on T cells as a heterodimer (CD8α/CD8β) acting as a co-receptor with TCR for MHC-I molecules.
It is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers.
Engagement with MHC-I/peptide complexes triggers Lck recruitment, leading to cytokine production and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are essential for pathogen and tumor cell clearance, with differentiation enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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