Thermo Fisher Scientific RTCA Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
LLANLRHGGT VDEYLQDQLI VFMALANGVS RIKTGPVTLH TQTAIHFAEQ IAKAKFIVKK SEDEEDAAKD TYIIECQGIG MTNPNL

Target Information

RTCD1 catalyzes the conversion of 3′-phosphate to a 2′,3′-cyclic phosphodiester at the end of RNA.
The mechanism of action occurs in three steps:

1. Adenylation of the enzyme by ATP
2. The enzyme acts on RNA-N3′P to produce RNA-N3′PP5′A
3. A non-catalytic nucleophilic attack by the adjacent 2′ hydroxyl on the phosphorus in the diester linkage to produce the cyclic end product

The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. There are two named isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.