Thermo Fisher Scientific c-Cbl Polyclonal Antibody
Thermo Fisher Scientific의 c-Cbl Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가진 Rabbit IgG 항체입니다. Western blot, IHC, ICC/IF에 사용 가능하며 고순도 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로 세포 신호 조절 관련 단백질 분석에 적합합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CBL (Product #RP-95275) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790148 |
Product Specific Information
Immunogen sequence:
PTTNVTEGSQ VPERPPKPFP RRINSERKAG SCQQGSGPAA SAATASPQLS SEIENLMSQG YSYQDIQKAL VIAQNNIEMA KNILREFVSI SSPAHVA
Target Information
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation.
Cbl-c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells, whereas other Cbl proteins are ubiquitously expressed.
Cbl-c, like other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation.
Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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