Thermo Fisher Scientific MED11 Polyclonal Antibody

Thermo Fisher Scientific MED11 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:500–1:1,000
Publications: 해당 없음

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen, and the purity is >95% (by SDS-PAGE).

Target Information

In mammalian cells, transcription is regulated by high molecular weight co-activating complexes that mediate signals between transcriptional activators and RNA polymerase II (Pol II). The mediator complex functions as a bridge between regulatory proteins and Pol II, thereby regulating Pol II-dependent transcription.

Med11 (mediator complex subunit 11) is a 117-amino-acid nuclear protein and a component of the mediator complex. The gene encoding Med11 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes, p53 and BRCA1, are associated with chromosome 17. Malfunction or loss of p53 expression is linked to malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair and is associated with predisposition to cancers of the ovary, colon, prostate gland, and fallopian tubes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.