Thermo Fisher Scientific TRIP10 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunocytochemistry (ICC/IF)

1:50-1:100

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 246-545 of human TRIP10 (NP_004231.1). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TRIP10,uniProtId:Q15642-1,ncbiNodeId:9606,antigenRange:246-545,antigenLength:601,antigenImageFileName:PA5-121057_TRIP10_Q15642-1_Rabbit.svg,antigenImageFileNamePDP:PA5-121057_TRIP10_Q15642-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.19 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914629

Product Specific Information

Positive test controls include: HepG2, HeLa, SKOV3, A673, 5637, Mouse kidney, Mouse heart, Mouse lung. The target is usually found in the following locations: Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Lysosome, cell cortex, cytoskeleton, perinuclear region, phagocytic cup.

Immunogen sequence: AKCLEGMKVA ANAVDPKNDS HVLIELHKSG FARPGDVEFE DFSQPMNRAP SDSSLGTPSD GRPELRGPGR SRTKRWPFGK KNKTVVTEDF SHLPPEQQRK RLQQQLEERS RELQKEVDQR EALKKMKDVY EKTPQMGDPA SLEPQIAETL SNIERLKLEV QKYEAWLAEA ESRVLSNRGD SLSRHARPPD PPASAPPDSS SNSASQDTKE SSEEPPSEES QDTPIYTEFD EDFEEEPTSP IGHCVAIYHF EGSSEGTISM AEGEDLSLME EDKGDGWTRV RRKEGGEGYV PTSYLRVTLN

Target Information

Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.