Thermo Fisher Scientific SIRP gamma Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.5 µg/mL

-

Flow Cytometry (Flow)

2.5 µg per million cells

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Sheep / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CHO-derived recombinant human SIRP gamma/CD172g Val64-Ser364, (Val263Ala) and (Ser286Leu) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SIRP gamma,uniProtId:Q9P1W8-1,ncbiNodeId:9606,antigenRange:64-364,antigenLength:387,antigenImageFileName:PA5-47627_SIRP_gamma_Q9P1W8-1_Sheep.svg,antigenImageFileNamePDP:PA5-47627_SIRP_gamma_Q9P1W8-1_Sheep_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2576834

Product Specific Information

In direct ELISAs, less than 5% cross-reactivity with recombinant human (rh) SIRP alpha, rhSIRP beta 1, and recombinant mouse SIRP alpha is observed.

Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

Target Information

SIRP gamma (CD172g) recognizes a 55 kDa signal regulatory protein which is a member of the immunoglobulin gene superfamily. SIRP gamma is expressed on most T lymphocytes and a subset of B-cells but is absent on myeloid cells. CD172g has a truncated cytoplasmic tail, which is similar to SIRP beta, but unlike SIRP beta CD172g does not require DAP12 for expression at the cell surface. CD172g, like SIRP alpha, binds to CD47 inducing apoptosis. SIRP gamma is also involved in the negative regulation of receptor tyrosine kinase-coupled signalling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.