Thermo Fisher Scientific ARPP21 Polyclonal Antibody
ARPP21 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제됨. Human 반응성, 액상 형태로 4°C 또는 -20°C에서 안정적으로 보관 가능.
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- PA553580
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- pk
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Thermo Fisher Scientific ARPP21 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ARPP21. Recombinant protein control fragment (Product #RP-90682). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.40 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638242 |
Product Specific Information
Immunogen sequence:
EQGDLNQAIA EEGGTEQETA TPENGIVKSE SLDEEEKLEL QRRLEAQNQE RRKSKSGAGK GKLTRSLAVC EESSARPGGE SLQDQESIHL QLSSFSSLQE EDKSRKDDSE REKEKDKNKD KTSEKPKIRM LSKDCSQEYT
Highest antigen sequence identity to orthologs:
- Mouse: 87%
- Rat: 88%
Target Information
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem, and spinal cord. ADCA types I–III are clinically distinguished, with genetic loci mapped to multiple chromosomes (SCA1–SCA6). ADCA is caused by expansion of CAG repeats, producing elongated polyglutamine tracts in proteins, leading to spinocerebellar ataxia type 1 (SCA1). The locus is mapped to chromosome 6, with diseased alleles containing 41–81 CAG repeats compared to 6–39 in normal alleles. At least two transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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