Thermo Fisher Scientific SCN4B Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SCN4B. Recombinant protein control fragment (Product #RP-90488). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SCN4B,uniProtId:Q8IWT1-1,ncbiNodeId:9606,antigenRange:50-152,antigenLength:228,antigenImageFileName:PA5-53579_SCN4B_Q8IWT1-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53579_SCN4B_Q8IWT1-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.10 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647015

Product Specific Information

Immunogen sequence: LLPCTFSSCF GFEDLHFRWT YNSSDAFKIL IEGTVKNEKS DPKVTLKDDD RITLVGSTKE KMNNISIVLR DLEFSDTGKY TCHVKNPKEN NLQHHATIFL QVV

Highest antigen sequence identity to the following orthologs: Mouse - 74%, Rat - 76%.

Target Information

The SCN4B protein modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. The protein has been found to be expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.