Thermo Fisher Scientific SCN4B Polyclonal Antibody
SCN4B 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 IHC(P) 실험에 적합하며, 항원 친화 크로마토그래피로 정제됨. 휴먼 SCN4B 재조합 단백질을 면역원으로 사용. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SCN4B. Recombinant protein control fragment (Product #RP-90488). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647015 |
Product Specific Information
Immunogen sequence:
LLPCTFSSCF GFEDLHFRWT YNSSDAFKIL IEGTVKNEKS DPKVTLKDDD RITLVGSTKE KMNNISIVLR DLEFSDTGKY TCHVKNPKEN NLQHHATIFL QVV
Highest antigen sequence identity to the following orthologs:
- Mouse: 74%
- Rat: 76%
Target Information
The SCN4B protein modulates channel gating kinetics. It causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. The protein is highly expressed in dorsal root ganglia and at lower levels in brain, spinal cord, skeletal muscle, and heart.
Defects in SCN4B are associated with long QT syndrome type 10 (LQT10) [MIM:611819], a heart disorder characterized by prolonged QT interval and polymorphic ventricular arrhythmias, potentially leading to syncope or sudden death under stress or exercise.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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