Thermo Fisher Scientific XPA Polyclonal Antibody
XPA 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot, IHC, IP에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, Human 시료에 반응합니다. UV 손상 DNA 복구 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:1,000
- Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of Human xeroderma pigmentosum, complementation group A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC: Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
The XPA (xeroderma pigmentosum group A) protein specifically recognizes UV- or chemically damaged DNA lesions and triggers the nucleotide excision repair process.
XPA binds to replication protein A (RPA) or excision repair cross complementing 1 protein (ERCC1).
In the absence of nucleotide excision repair, persisting DNA lesions may lead to gene mutations and ultimately to cancer.
Xeroderma pigmentosum patients have a >2000-fold increased risk of developing skin cancer at sun-exposed areas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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