Thermo Fisher Scientific CD304 (Neuropilin-1) Monoclonal Antibody (XML1Y1), eBioscience
CD304 (Neuropilin-1)을 인식하는 XML1Y1 단클론 항체로, 인간 및 마우스 시료에 반응합니다. IHC(F) 및 ICC/IF에 적합하며 VEGF 수용체 복합체 연구에 활용됩니다. 0.5 mg/mL 농도의 액상 항체로, 4°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | XML1Y1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572874 |
| Purity | >90% (SDS-PAGE) |
| Aggregation | <10% (HPLC) |
| Filtration | 0.2 µm post-manufacturing filtered |
Product Specific Information
The monoclonal antibody XML1Y1 recognizes CD304 (Neuropilin-1), a type I transmembrane glycoprotein expressed on various cell types including regulatory T cells (Tregs), NKT cells, dendritic cells, stem cells, neurons, endothelial cells, and some tumor cells.
Neuropilin-1 acts as a co-receptor for type 3 semaphorins in neurons and participates in angiogenesis as part of the VEGF receptor complex in endothelial cells. In mice, Neuropilin-1 is expressed on thymus-derived natural Tregs but not on peripherally induced Tregs, and transiently on recently activated non-regulatory T cells. It serves as a marker for recent thymic emigrants in mouse iNKT cells.
Neuropilin-1 forms complexes with TGF-β receptors, activating latent TGF-β and enhancing Smad2/3 signaling. This XML1Y1 antibody recognizes neuropilin-1 isoforms 1 and 2.
Applications Reported:
- Immunohistochemical staining of frozen tissue sections
- Immunocytochemistry
Applications Tested:
- IHC(F): ≤1 µg/mL (acetone-fixed frozen sections)
- ICC/IF: ≤1 µg/mL (methanol-fixed bEND3 cells)
Careful titration is recommended for optimal performance.
Target Information
Neuropilin-1 is a 923-amino-acid membrane-bound coreceptor belonging to the neuropilin family. It contains two CUB domains, two F5/8 type C domains, and a MAM domain. Neuropilin-1 forms heterodimers with Neuropilin-2 (NRP2) and binds plexin (PLXNB1) to form semaphorin receptors.
Primarily expressed in the nervous system, Neuropilin-1 is involved in cardiovascular development, angiogenesis, axon guidance, neuronal circuit formation, cell survival, neuronal migration, and organogenesis. It also functions as a receptor for semaphorins and VEGF, regulating VEGF-induced angiogenesis.
Neuropilin-1 expression has been associated with aggressive prostate and breast cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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