Thermo Fisher Scientific SLC28A1 Polyclonal Antibody
Thermo Fisher Scientific의 SLC28A1 폴리클로날 항체는 인간, 마우스, 랫트 시료에 반응하며 Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제된 고순도 제품으로, 71 kDa 단백질을 검출합니다. 연구용으로만 사용 가능합니다.
- 판매단위
- pk
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Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in human SLC28A1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553972 |
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 71 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Nucleosides play a role in signaling in several physiologic systems, and synthetic analogs of natural nucleosides are often used to treat neoplastic and viral diseases.
Plasma membrane transport of nucleosides is mediated by equilibrative and concentrative nucleoside transporters, which may have specificity for purines or pyrimidines.
The deduced human 650 amino acid concentrative nucleoside transporter 1 (CNT1) protein is 83% identical to the rat protein and is expressed in the intestine, kidney, and liver.
CNT1, also designated solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (SLC28A1), expedites sodium-dependent fluxes of uridine, azidodeoxythymidine (AZT), and adenosine, but not of guanosine or deoxyadenosine, which undergo net renal secretion.
CNT1 activity may serve as a putative mechanism for renal reabsorption of physiologic nucleosides and synthetic nucleoside drugs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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