Thermo Fisher Scientific TRADD Polyclonal Antibody
TRADD 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간, 마우스, 랫트 등 다양한 종에 반응합니다. Western blot 및 Immunoprecipitation에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
- 카탈로그번호
- PA517465
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunoprecipitation (IP)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding cysteine 138 of human TRADD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 81 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11009632 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
TRADD (Tumor necrosis factor receptor type 1-associated DEATH domain protein) is an important mediator of FAS and TNFR1-associated apoptotic signaling. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12. TRADD interacts with TRIP12, disrupting the interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. It acts as an adapter molecule for TNFRSF1A/TNFR1, associating with the cytoplasmic domain of activated TNFRSF1A/TNFR1 to mediate its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses: apoptosis and activation of NF-kappa-B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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