Thermo Fisher Scientific CD31 Monoclonal Antibody (MEM-05), APC
인간 CD31(PECAM-1)을 인식하는 마우스 모노클로날 항체로, APC로 표지되어 유세포분석(Flow Cytometry)에 적합합니다. 4°C에서 어둡게 보관하며 동결 금지. PBS(pH 7.4)와 0.2% BSA, 15mM sodium azide 포함. 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow): 10 µL / 1×10⁶ cells
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-05 |
| Immunogen | Leukocytes of patient suffering from LGL-type leukaemia |
| Conjugate | APC |
| Excitation/Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155400 |
Additional Formats
- Unconjugated (MA1-19199)
- Alexa Fluor 488 (MA5-18135)
- Biotin (MA1-19510)
- FITC (MA1-19587)
- PE (MA1-19769)
- Request custom conjugation
Product Specific Information
This antibody reacts with an extracellular epitope of CD31 (PECAM-1), a 130–140 kDa type I transmembrane glycoprotein expressed on monocytes, platelets, granulocytes, endothelial cells, and stem cells of the myeloid lineage.
Target Information
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling through dual immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Upon phosphorylation by associated kinases, these motifs provide docking sites for protein-tyrosine phosphatases.
CD31 is ubiquitously expressed within the vascular compartment, mainly at junctions between adjacent cells. Its N-terminal Ig-like domain mediates homophilic binding, playing a crucial role in cell-cell interactions.
CD31 functions in modulation of integrin-mediated adhesion, transendothelial migration, angiogenesis, apoptosis, regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis, and thrombosis, serving as a key regulatory molecule in the vascular system.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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