Thermo Fisher Scientific Kir4.1 (KCNJ10) Polyclonal Antibody
Kir4.1(KCNJ10) 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P) 실험에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관하며 -20°C에서 안정적으로 저장 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KCNJ10 (Accession P78508), corresponding to amino acid residues R199–L249 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852978 |
Product Specific Information
Antibody detects endogenous levels of total KCNJ10.
Target Information
The KIR (inwardly rectifying potassium channel) family of potassium channels preferentially allow potassium ions to flow into the cell rather than out.
KIR4.1 (also known as Kir1.2) is highly expressed in brain tissues including glial cells, astrocytes, and cortical neurons. It is also present in myelin-synthesizing oligodendrocytes and plays a critical role in myelination during nervous system development.
The human KIR4.1 gene maps to chromosome 1.
KIR4.2 (Kir1.3) is expressed in kidney, lung, heart, thymus, and thyroid during development, and its gene maps to chromosome 21, within the Down syndrome chromosome region 1, suggesting a potential role in Down syndrome pathogenesis.
KIR5.1 forms functional channels only when coexpressed with either KIR4.1 or KIR4.2 in kidney and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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