Thermo Fisher Scientific Beta-catenin Monoclonal Antibody (OTI1F3), TrueMAB
Beta-catenin 단백질을 검출하기 위한 Mouse IgG2a 단클론 항체로, WB 및 IHC(P)에서 사용 가능. Human 및 Dog 반응성. Lyophilized 형태로 제공되며 PBS buffer에 trehalose 포함. 세포 접착 및 신호전달 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F3 |
| Immunogen | Human recombinant protein fragment (aa 531–781 of human beta-catenin, produced in E. coli) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitution: Add 100 µL distilled water to achieve ~1 mg/mL concentration.
- For conjugation experiments, perform desalting (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and epithelial layer formation. It interacts with E-cadherin and alpha-catenin, linking adhesion complexes to the actin cytoskeleton.
Beta-catenin also associates with signaling pathways involving tyrosine kinases, phosphatases, and Wnt/Wingless, influencing morphogenesis and tumorigenesis.
In the nucleus, beta-catenin coactivates Lef/Tcf transcription factors, promoting the expression of genes such as cyclin D and c-myc that drive cell proliferation.
Aberrant beta-catenin activity is implicated in various cancers including colorectal, ovarian, breast, liver, lung, gastric, prostate, and skin tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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