Thermo Fisher Scientific Sox17 Monoclonal Antibody (OTI3H5), TrueMAB
SOX17 단백질을 표적으로 하는 Mouse IgG2a 형 단일클론 항체. Western blot 및 Immunocytochemistry에 적합. 무보존제, 동결건조 형태로 제공되며 재구성 후 1 mg/mL 농도 유지. 배아 발달 및 Wnt 신호 조절 연구용으로 최적화된 TrueMAB 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2500–1:5000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3H5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 177–414 of human SOX17 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
For reconstitution, add 100 µL distilled water to reach a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
SOX17 (transcription factor SOX-17) belongs to the SRY-related HMB box family of transcription factors.
It acts as a transcription regulator that binds target promoter DNA and bends the DNA, recognizing sequences 5'-AACAAT-3' or 5'-AACAAAG-3'.
SOX17 modulates transcriptional regulation via WNT3A and inhibits Wnt signaling by promoting degradation of activated CTNNB1.
It plays an essential role in embryonic development, including heart tube looping and definitive gut endoderm formation.
Mutations in SOX17 can lead to vesicoureteral reflux.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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