Thermo Fisher Scientific CD23 Monoclonal Antibody (EBVCS2), PerCP-Cyanine5.5, eBioscience

Applications

Tested Application

• Flow Cytometry (Flow): 5 µL (0.25 µg)/test
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Product Specifications

Additional Formats Available

• Unconjugated
• APC
• APC-eFluor 780
• Brilliant UV 805
• eFluor 450
• FITC
• NovaFluor Blue 660-120S
• NovaFluor Blue 690
• NovaFluor Red 685
• NovaFluor Red 700
• NovaFluor Red 755
• NovaFluor Yellow 610
• NovaFluor Yellow 660
• NovaFluor Yellow 700
• NovaFluor Yellow 755
• PE
• PE-Cyanine7
• PE-eFluor 610
• Super Bright 436
• Super Bright 600
• Super Bright 702
• Request custom conjugation

Product Specific Information

The EBVCS2 monoclonal antibody reacts with human CD23, a 45 kDa type II transmembrane glycoprotein.
CD23 is expressed on mature B cells, mantle zone B cells, follicular dendritic cells, and at low levels on T cells, NK cells, Langerhans cells, and platelets.

• Expression of CD23 increases upon B cell activation.
• Soluble CD23 forms are biologically active.
• CD23 acts as a low affinity receptor for IgE and regulates IgE responses and B cell activation.
• CD21 and α subunits of CD11b/CD11c bind to CD23.

Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-titrated and tested on normal human peripheral blood cells.
Use at 5 µL (0.25 µg) per test in a final volume of 100 µL.
Cell number may vary from 10⁵ to 10⁸ cells/test.

Excitation: 488 nm
Emission: 695 nm
Laser: Blue Laser
Filtration: 0.2 µm post-manufacturing filtered

Target Information

CD23 is a 45 kDa glycoprotein found on a subset of peripheral blood and tonsil B cells, and highly expressed on EBV-transformed B lymphoblasts.
It is identical to the low affinity IgE receptor on B cells.
CD23 expression is observed in neoplastic cells from chronic lymphocytic leukemia and centroblastic/centrocytic lymphoma.

Functionally, CD23 is involved in:

• B cell growth and differentiation
• IgE production
• Soluble CD23 acts as a potent mitogenic factor

Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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