Thermo Fisher Scientific ADAMTS7 Polyclonal Antibody
ADAMTS7 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot 및 IHC(파라핀 절편)에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 고순도(>95%)를 보장합니다. 인간 샘플에 반응하며 연구용으로만 사용됩니다.
- 카탈로그번호
- PA575869
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in Human ADAMTS7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719597 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) is a family of zinc-dependent proteases involved in various physiological and pathological processes such as arthritis and cancer. Members of this family have an N-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain, and a C-terminus containing multiple thrombospondin type-1 (TSP-1) motifs.
ADAMTS-7 (ADAM metallopeptidase with thrombospondin type 1 motif, 7), also known as COMPase, is a 1,686 amino acid protein encoded on human chromosome 15q25.1. It contains eight TSP-1 motifs and binds one zinc ion per subunit. ADAMTS-7 is expressed in multiple tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas, as well as in meniscus, bone, tendon, cartilage, synovium, fat, and ligaments. It is upregulated in articular cartilage and synovium of arthritis patients and functions as a metalloprotease possibly involved in COMP degradation. Its enzymatic activity is pH-dependent, with optimal activity between pH 7.5 and 9.5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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