Thermo Fisher Scientific BID Polyclonal Antibody
Thermo Fisher Scientific의 BID Polyclonal Antibody는 마우스 BID 단백질을 인식하는 고품질 토끼 다클론 항체입니다. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 사멸 연구 및 미토콘드리아 손상 메커니즘 분석에 유용합니다.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding the cleavage site of mouse BID |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10978504 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. It is a member of the BCL-2 family of cell death regulators and mediates mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the COOH-terminal fragment translocates to mitochondria, triggering cytochrome c release. BID functions as a pro-apoptotic molecule linking caspase 8 activation to mitochondrial death pathways. In living cells, BID exists in an inactive cytosolic form and becomes activated by caspase 8 in response to TNF alpha or Fas ligand. The cleaved C-terminal 15 kDa fragment (p15) is sufficient to induce cytochrome c release and apoptosis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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