Thermo Fisher Scientific Phospho-p130Cas (Tyr267) Polyclonal Antibody
p130Cas 단백질의 Tyr267 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot과 IHC(Paraffin)에서 사용 가능. 인간, 마우스, 랫트 반응성. 1 mg/mL 농도의 액상 형태로, PBS/glycerol buffer에 보관. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCAR1 (Accession P56945), corresponding to amino acid residues around phosphorylated Tyr267 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817022 |
Product Specific Information
This antibody detects endogenous levels of p130Cas only when phosphorylated at Tyr267.
Target Information
The p130Cas (Crk-associated substrate) is a common cellular target of phosphorylation signaling via v-Crk and v-Src oncoproteins. It contains an SH3 domain followed by multiple YXXP motifs and a proline-rich region. p130Cas is involved in processes such as cell adhesion, migration, growth factor stimulation, cytokine receptor engagement, and bacterial infection. It plays roles in cardiovascular development, actin filament assembly, and Src-induced cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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