Thermo Fisher Scientific GPR55 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) [IHC (P)]

• Tested Dilution: 5–10 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human (100%), Gorilla, Gibbon, Monkey, Marmoset, Hamster, Bovine, Dog, Horse (94%), Elephant, Panda, Bat (88%).

Target Information

GPR55 is expressed in the brain, with mRNA transcripts detected in the caudate nucleus and putamen, but not in five other brain regions (Sawzdargo et al., 1999). ESTs have also been isolated from liver/spleen libraries.
G-protein Coupled Receptors (GPCRs) represent one of the largest families of signaling molecules with over a thousand predicted members. They share a structural motif of seven membrane-spanning helices and exist in active and inactive forms. Activating ligands induce conformational changes leading to G-protein signaling and downstream effects.
Studies have shown complex mechanisms in the negative regulation of GPCRs, with significant implications for cellular physiology and drug discovery. GPCR-targeted pharmaceuticals such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough) are notable examples with major market presence in mental health and allergy treatments.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.