Thermo Fisher Scientific SHIP1 Recombinant Rabbit Monoclonal Antibody (SY11-08)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences are cloned from immunoreactive rabbits, and individual clones are screened to select the best candidates for production.

Key advantages:

• Improved specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broad immunoreactivity due to larger rabbit immune repertoire

Target Information

The SHIP1 gene belongs to the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with:

• N-terminal SH2 domain
• Inositol phosphatase domain
• Two C-terminal protein interaction domains

Expression is restricted to hematopoietic cells, where movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5′ phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby modulating multiple signaling pathways. It functions as a negative regulator of myeloid cell proliferation and survival. Alternate splice variants encoding different isoforms have been characterized.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.