Thermo Fisher Scientific CIP2A Monoclonal Antibody (2G10), HRP
CIP2A 단백질을 표적으로 하는 HRP 결합 단클론 항체로, Western blot 및 IHC(P) 분석에 적합. 인간, 마우스, 비인간 영장류, 랫트 반응성. Protein G 정제, PBS 버퍼, 무방부제. 암 연구 및 c-Myc 관련 세포 변형 연구에 활용 가능.
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Thermo Fisher Scientific CIP2A Monoclonal Antibody (2G10), HRP
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2G10 |
| Immunogen | A C-terminal portion of the human p90 protein |
| Conjugate | HRP |
| Form | Liquid |
| Concentration | 1.8 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_11154278 |
Additional Formats
Target Information
Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein designated Cancerous Inhibitor of PP2A (CIP2A) interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation.
In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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