Thermo Fisher Scientific ESX1 Polyclonal Antibody
Thermo Fisher Scientific의 ESX1 Polyclonal Antibody는 인간 ESX1 단백질을 인식하는 토끼 유래 다클론 항체입니다. Western blot과 IHC에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 완충액에 0.02% sodium azide가 포함되어 있습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid peptide near the center of human ESX1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at −20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152286 |
Product Specific Information
- Suggested positive control: human testis tissue lysate
- PA5-20896 can be used with blocking peptide PEP-1010
Target Information
Homeobox proteins are transcription factors that contain a helix-turn-helix DNA binding domain termed the homeodomain.
ESX1 is an X-linked homeobox gene primarily expressed in the placenta and testis and contains two functional domains: the homeodomain and the proline-rich domain.
During embryogenesis, ESX1 is expressed in the extraembryonic tissues, including the endoderm of the visceral yolk sac, the ectoderm of the chorion, and the labyrinthine trophoblast of the chorioallantoic placenta.
ESX1 can act as a transcriptional repressor to the human oncogene K-ras. Treatment of human cancer cells with an ESX1 protein fragment containing the homeodomain reduces the tumorigenicity of cells containing oncogenic K-ras mutations, suggesting ESX1 may be useful as a therapeutic target for these cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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