Thermo Fisher Scientific PLK4 Polyclonal Antibody
PLK4 단백질을 인식하는 Thermo Fisher Scientific의 염소 폴리클로날 항체. Western blot, ICC/IF, Flow Cytometry 등 다양한 응용에 사용 가능. 인간, 소, 개 종에 반응 예측. 액상 형태로 -20°C 보관.
- 카탈로그번호
- PA518012
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | |
| Immunocytochemistry (ICC/IF) | Assay-dependent | |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (ATCIGEKIEDFKVGN) corresponding to the N-terminus amino acids of PLK4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10981865 |
Product Specific Information
This antibody is predicted to react with bovine and canine based on sequence homology.
Target Information
PLK4 (Polo-like kinase 4) is a member of the polo family of serine/threonine protein kinases. It localizes to centrioles—complex microtubule-based structures found in centrosomes—and regulates centriole duplication during the cell cycle. Overexpression of PLK4 triggers the formation of multiple procentrioles around each preexisting centriole, resulting in centriole amplification and Plk4-induced centriole biogenesis in human cells. Reduced Plk4 gene dosage increases the probability of mitotic errors and cancer development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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