Thermo Fisher Scientific SPIRE2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SPIRE2. Recombinant protein control fragment (Product #RP-98593). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SPIRE2,uniProtId:Q8WWL2-1,ncbiNodeId:9606,antigenRange:612-712,antigenLength:714,antigenImageFileName:PA5-61960_SPIRE2_Q8WWL2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61960_SPIRE2_Q8WWL2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647871

Product Specific Information

Immunogen sequence: HIPVYTLGFE SPQRVSAAKT APIQRRDIFQ SLQGPQWQSV EEAFPHIYSH GCVLKDVCSE CTSFVADVVR SSRKSVDVLN TTPRRSRQTQ SLYIPNTRTL D

Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 81%.

Target Information

Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.