Thermo Fisher Scientific Transferrin Receptor Monoclonal Antibody (OX-26)
Transferrin 수용체(CD71)를 인식하는 OX-26 단클론 항체로, Western blot, IHC(F), Flow cytometry, IP에 사용 가능. Rat 시료에 반응하며, Protein G로 정제된 1 mg/mL 액상 항체. 철 흡수 및 적혈구 발달 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 0.5 µg/mL | |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | |
| Flow Cytometry (Flow) | 0.5 µg/1×10⁶ cells | |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OX-26 |
| Immunogen | PHA activated lymph node cells of a PVG rat |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073357 |
Additional Formats
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.
Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from various conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome, and HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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