Thermo Fisher Scientific TAK1 Monoclonal Antibody (3E8H4)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1:10,000

Product Specifications

Product Specific Information

This antibody has been tested in indirect ELISA.

Target Information

TAK1 (also known as MAP3K7) is a serine/threonine kinase involved in multiple signaling pathways. It was initially identified as a TGF-β-activated kinase and interacts with TGF-β receptor and TRAF6 to modulate activation of JNK and p38. TAK1 also participates in signaling through Wnt, BMP, activin, thyroid hormone, osmotic stress, endothelin, and ephrine pathways. It regulates wound healing via activation of von Hippel-Lindau tumor suppressor expression and represses PDGF-B and integrins β1/β5. TAK1 plays a crucial role in IKK activation across pathways such as IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination, followed by TAK1 autophosphorylation at Thr178, Thr184, Thr187, and Ser192, leading to phosphorylation of IKK-β. TAK1 also represses human telomerase reverse transcriptase, suggesting involvement in cell lifespan regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.