Thermo Fisher Scientific Beta-catenin Monoclonal Antibody (OTI2F10), TrueMAB
Beta-catenin 단백질을 인식하는 Mouse monoclonal antibody로, Western blot 및 IHC(Paraffin)에서 검증됨. Human 시료에 반응하며, Lyophilized 형태로 제공. 세포 접착 및 Wnt 신호전달 연구에 적합. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 29–118 of human CTNNB1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Beta-catenin is an adherens junction (AJ) protein essential for cell-cell adhesion and epithelial layer maintenance. It interacts with E-cadherin and alpha-catenin, linking the adhesion complex to the actin cytoskeleton.
Beta-catenin also associates with adenomatous polyposis coli (APC) protein, microtubules, and participates in Wnt/Wingless signaling pathways.
It plays a key role in morphogenesis, cell proliferation, and tumorigenesis, being implicated in cancers such as colorectal, ovarian, breast, liver, and skin cancers.
In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors to stimulate genes like cyclin D and c-myc.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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