Thermo Fisher Scientific Bestrophin Polyclonal Antibody, FITC
FITC로 표지된 Bestrophin 폴리클로날 항체로, 인간, 마우스, 랫트 시료에 반응합니다. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합하며, 액상 형태로 제공됩니다. Affinity chromatography로 정제되었으며, -20°C에서 암소 보관이 권장됩니다.
- 카탈로그번호
- BEST1-1-FITC
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | N-epitope synthetic peptide corresponding to unique amino acid sequences on human Bestrophin 1 protein |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The retinal pigment epithelium (RPE) and choroid represent a differentiated system of the eye that sustains normal retinal health and function.
Best vitelliform macular dystrophy (Best disease) is an early-onset autosomal dominant condition characterized by accumulation of lipofuscin-like material within and beneath the RPE, leading to progressive central vision loss.
This material appears as a yellow mass that darkens and becomes irregular over time, a process known as “scrambling the egg.”
Best disease is often associated with mutations in the Bestrophin gene, which encodes a protein with four transmembrane domains localized to the basolateral plasma membrane of RPE cells.
Human Bestrophin forms oligomeric chloride channels sensitive to intracellular calcium, and missense mutations can reduce or abolish membrane current mediated by this protein.
The human Bestrophin gene encodes a 585 amino acid protein.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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